胡颖 中国
暂无描述
教授||博士生导师
目前就职生命科学与技术学院
所在学科 生物医学工程
永久地址 http://homepage.hit.edu.cn/huying

Personal information

 

 

 

 

 

Ying Hu


 

Ying Hu

PhD, Professor
Phone: 86-0451-86403992
Email: huying@hit.edu.cn
Research Area:Biological functions of proto-oncogene and tumor suppressor
Lab Home: http://life.hit.edu.cn/News/Show_e.asp?id=4304


胡颖博士的研究室主要进行肿瘤生物学领域特别是对癌基因和抑癌基因功能的探讨。p53基因是在人类肿瘤中最常见的突变基因。50%以上的肿瘤含有p53基因的突变,而野生型p53的肿瘤也往往伴有p53信号传导通路组份的缺陷。明确p53的生物学功能及其调控机制对于深入理解肿瘤发生的分子机制至关重要。胡颖博士的研究兴趣主要是探讨p53信号的分子机制,特别是解剖p53家族成员与其上游调控蛋白,如ASPPs,之间的相互作用,在分子和细胞水平,利用肿瘤细胞模型和临床人体癌组织样本进行肿瘤分子机制的研究。同时关注ASPPs基因表达调控的机制,并对该组蛋白的未知功能进行探讨。目前实验室使用的方法和技术主要包括体外细胞培养,MTT,Western印迹,RT-PCR,流式细胞仪,分子克隆,软琼脂和其他多种分子和细胞生物学工具,以为人类恶性疾病提供重要的生物标志物和治疗靶点为己任。

 

Professor Ying Hu’s laboratory mainly focused on cancer biology specifically in the field of proto-oncogene and tumor suppressor’s functions. p53 is the most frequently-mutated gene in human tumors. Over 50% of all tumors and almost every type of tumor contain p53 mutations, whereas wild type p53 tumors are often accompanied with the defects in p53 signaling components. No doubt, revealing p53’s functions and its regulatory mechanisms is critical for understanding the molecular mechanisms of oncogenesis. Dr. HU’s research interest is to investigate p53 signaling and particularly to dissect the interactions of p53 family members with other upstream regulatory proteins, such as ASPPs. Her group is focused on the translational and posttranslational regulatory mechanisms of ASPPs. Another paradigm of their work is to reveal p53-independent biological functions of ASPPs. The research in the lab is carried out at molecular and cellular levels using both cancer cells models and clinical human cancer tissue samples. The methods and technologies used in her current lab include in vitro cell culture, MTT, Western Blotting, FACS, RT-PCR, molecular cloning, soft agar assay and many other molecular and cellular tools. The goal of laboratory is to develop clinically relevant biomarkers and therapeutic targets for human malignancy diseases.

 

 

Working experiences

 2012.4-               Professor, Harbin Institute Of Technology

2009.11-2012.1  Postdoctoral Molecular Biologist, Ludwig Institute for Cancer Research, University of Oxford

2009.6-2009.11  Researcher scientist, University of Oxford

Education experiences

 

1994.09-1999.07    M.B. in Chemical Analysis, School of Public Health, Shandong Medical University.

1999.09-2002.07    M.S. in Biochemistry and Molecular Biology, Shanghai Institute for Cancer Research 

                               Medical Center of Fudan University.

2002.09-2004.09    Mphil in Clinical Oncology, Chinese University of HongKong.

2004.10-2009.09    PhD in Cancer Biology,University College London.

 

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