顾宁 中国
糖尿病、纳米、小分子
教授
目前就职生命科学与技术学院
所在学科 生物医学工程
永久地址 http://homepage.hit.edu.cn/guning

基本信息


   顾宁,男,汉族,1973年生。教授,博士生导师;哈尔滨工业大学生命科学与技术学院

研究领域

       顾宁教授于2010年1月,被哈尔滨工业大学生命与工程系以海外人才的形式引进,并获得国家自然科学基金及哈尔滨工业大学科研启动基金的资助。现在,主要从事有关药理学与内分泌疾病领域的研究.

      现主要研究方向:

1. 糖尿病,肥胖症等内分泌疾病的发病机制和治疗方法的研究

2. 纳米粒子及小分子化合物的药理及毒理研究


      现负责科研项目有:

1.【纳米材料对不同发育时期小鼠血糖代谢的影响及其机制的研究】

国家自然科学基金   2017-2020  负责人

2.【特定的转录因子重组蛋白质诱导成纤维细胞直接重编程为软骨细胞及其安全性的研究】

国家自然基金   2012-2016 负责人

3.【水环境中TiO2纳米颗粒对血糖代谢的影响极其机制的研究】

城市水资源与水环境国家重点实验室   2015-2016  负责人

4.【转录因子重组蛋白改善间充质干细胞增殖能力的研究】

黑龙江省归国留学基金   2012-2015 负责人

5.【水环境中的纳米粒子对内分泌系统的毒理效应及其机制的研究】   

城市水资源与水环境国家重点实验室    2011-2014  负责人

6.【关于改善重组蛋白诱导iPS细胞效率的研究】  

国家自然科学基金   2011-2011 负责人

工作经历

时间 工作经历

2016.1-

2010.1-2015.12

哈尔滨工业大学 生命科学与技术学院 教授

哈尔滨工业大学 生命科学与技术学院 副教授    

2009.4-2010.1 日本 产业技术综合研究所   研究员
2007.4-2009.3 日本 京都大学       学术振兴会(JSPS)研究员

 

教育经历

  1. 2004.4-2007.3    日本 京都大学          博士
  2. 2002.4-2004.3    日本 京都大学          硕士
  3. 1998.4-2002.3    日本 京都教育大学        学士

科研成果

发表论文20余篇:

1) Hu Hailong, Li Li, Guo Qian, Jin Sanli, Zhou Ying, Oh Yuri, Feng Yujie, Wu Qiong, Ning Gu, A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice. Food Chem Toxicol, 2016, 95:175-187.

2) Gu Ning, Hu Hailong, Guo Qian, Jin Sanlin, Wang Changlin, Oh Yuri, Feng Yujie, Wu Qiong, Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food Chem Toxicol, 2015, 86:124-131.

3) Gu Ning, Guo Qian, Mao Ke, Hu Hailong, Jin Sanlin, Zhou Ying, He Hongjuan, Oh Yuri, Liu Chuanpeng, Wu Qiong, Plasmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes. Biochem Biophys Res Commun, 2015, 467: 521-526.

4) Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. J. App. Toxicol. 2015.

5) Hu Hailong, Li Li, Wang Changlin, He Hongjuan, Mao Ke, Ma Xiao, Shi Ruoyu, Oh Yuri, Zhang Fengwei, Lu Ying, Wu Qiong, Gu Ning, 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33(6):1899-910.

6) Wang CL, Diao YX, Xiang Q, Ren YK, Gu Ning, Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. Eur J Pharmacol. 2014 Sep 5;738:1-7. 

7) Wang CL, Xiang Q, Diao YX, Ren YK, Gu Ning, Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. Eur J Pain. 2014 Sep;18(8):1157-64.

8) Wang CL, Ren YK, Xiang Q, Wang Y, Gu Ning, Lu C, Wang R, Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides. 2013 Oct;47(5):297-304.

9) Gu Tiantian, He Hongjuan, Xing Yanjiang, Liu Qi, Gu Ning, Sugimoto Kenkichi, Jiang Huijie and Wu Qiong. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. J Mol Histol. 2011 Feb 9  [Epub ahead of print]

10) Ikegami Dasuke, Iwai T, Ryo Senyi, Gu Ning, Sugiyama Tasuke, Oh Isamu, Yoshikawa Hiroyuki, Tsumaki Nobuyuki. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage. Osteoarthritis Cartilage. 19(2), 233-41 2011.

11) Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. Diabetes Technol. Ther. 12(2):125-133, Feb, 2010.

12) Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. Clin Exp Pharm Phys. 35(12), 1433-1439, May, 2008.

13) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. Biochem Biophys Res Commun. 353(3), 617-622, Feb, 2007.

14) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 346(3), 1016-1023, Aug, 2006.

15) Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells. J Nutrl Sci Vitaminol. 52(2), 105-112, Apr, 2006.

16) Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cells. Biochem Biophys Res Commun. 325(1), 308-313, Oct, 2004.

17) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Characteristics of skeletal muscle in rats with diabetes, hypertension, obesity,and hyperlipidemia. J Atheroscler Thromb. 16(5), 576-585, Oct, 2009.

18) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Okiur Tomonori, Morimatsu Fumiki, Takeda Isao, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygen concentration on reactive oxygen metabolites in type II collagen-induced arthritis rats. Free Radical Research (accepted Aug, 2009).

19) Matsunaga Tetsuro, Gu Ning, Yamazaki Hanae, Tsuda Mariko, Adachi Tetsuya, Yasuda ,Koichiro, Moritani, Toshio, Tsuda Kinsuke, Nonaka Masahiko, Nishiyama Tohru. Association of UCP2 and UCP3 polymorphisms with autonomic nervous system functionin young Japanese males. J Hypertens. 27(2), 305-313, 2009.

20) Okiura Tomonori, Nagatomo Fumiko, Gu Ning, Taguchi Yasuki, Morimatsu Fumiki and Ishihara Akihiko. Bone density of the femur and fFiber cross-sectional area and oxidative enzyme activity of the tibialis anterior muscle in type II collagen-induced arthritic mice. J Physiol Sci. 58(4), 221-227, 2008.

21) Koyanagi Midori, Nakabayashi Kazuhiko, Fujimoto Takahiro, Gu Ning, Baba Iwai, Sasazuki Takehiko and Shirasawa Senji. ZFAT expression in B and T lymphocytes andidentification of ZFAT-regulated genes. Genomics. 91(5), 451-457, 2008.

22) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Matsumoto Akiko, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygenconcentration on glucose and insulin levels and skeletal muscle fiber properties in diabetic Goto-Kakizaki rats. Muscle Nerve. 35(3), 337-343, 2007.

23) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. Am Heart J.154(4), 759-766, 2007.

24) Adachi Tetsuya, Kikuchi Naoko, Yasuda Koichiro, Anahara Reko, Gu Ning, Matsunaga Tetsuro, Yamamura Tsubasa, Tsujimoto Gozou, Tsuda Kinsuke, Ishihara Akihiko. Fiber type distribution, succinate dehydrogenese and peroxisome proliferator- activatedreceptor gamma coactivator- 1alpha gene expression level of fibers in the soleus muscle of Zucker diabetic fatty rats. Exp Physiol. 92(2), 449-455, 2007.

25) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Tsuda Kinsuke, Kikuchi Naoko, Matsunaga Tetsuro, Ishihara Akihiko. Hyperbaric exposure with high oxygen concentration inhibits growth-associated increase in the glucose level of diabetic Goto-Kakizaki rats. Diabetes Obes Metab. 8(6), 714-715, 2006.

26) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. J Hum Genet. 52(1), 28-37, 2006.

27) Matsunaga Tetsuro, Nagasumi Kae, Gu Ning, Nishikino Mariko, Ueda Yukihiko, Moritani Toshio, Aoki Norihiko, Tsuda Kinsuke, Yasuda Koichiro. Association of C825T Polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy japanese individuals. Am J Hypertens. 18(4), 523-529, 2005.

28) Yasuda Koichiro, Matsunaga Tetsuro, Moritani Toshio, Nishikino Mariko, Gu Ning, Yoshinaga Mariko, Nagasumi Kae, Yamamura Tsubasa,, Tsuda Kinsuke. T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects. Clin Exp Pharm Phys. 31(9), 597-601, 2004.

专利

1) 顾宁, 胡海龙, 毛轲, 郭倩. 一种促进肌肉细胞中GLUT4基因表达的方法: 中国, CN103820384A. 2014-05-28.

2) 顾宁, 胡海龙, 郭倩, 毛轲. SB505124在制备治疗软骨损伤的药物中的应用: 中国, CN103961352A. 2014-08-06.

3) 顾宁, 岳磊, 胡海龙. 一种提高人间充质干细胞分化能力的方法: 中国, CN104004711A. 2014-08-27.

4) 顾宁, 马卓, 胡海龙, 郭倩. 一种新的检测组织中纳米颗粒的方法: 中国, CN104198510A. 2014-12-10.

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